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Depletion of HDL-C in depression may impair these protective functions, exacerbating neuroinflammation and oxidative stress—key drivers of synaptic dysfunction and neuronal apoptosis (69, 70)

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In this model, GPx-1 overexpression was found to improve subsequent spatial learning after brain injury in young mice, possibly due to the early reduction in oxidative injury in mice with excess GPx-1 compared to wild-type mice (363)